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COX-2 Inhibitors – Celebrex and Bextra

In-depth information about COX-2 Inhibitors, anti-inflammatory medications such as Bextra and Celebrex for osteoarthritis and back problems

Spinal arthritis medications
May 25, 2005
Patients with spinal arthritis have several options for medications to control the pain. Among other factors, the level of the patient’s pain and the potential side effects of the medication must be considered. Potential medications for managing spinal arthritis symptoms include: acetaminophen, topical analgesics, NSAIDs and COX-2 inhibitors, cortisone injections, and nutritional supplements such as glucosamine and chondroitin. Read more...
By: Vert Mooney, MD

Effectiveness of glucosamine and chondroitin sulfate for osteoarthritis (Research article)
April 19, 2005
Although there is not yet a proven treatment to stop or slow the progression of osteoarthritis, glucosamine and chondroitin sulfate nutritional supplements may provide a viable alternative for some patients. An FDA study on the effects and safety of glucosamine and chondroitin dietary supplements is currently underway, and many physicians support their use because of the low incidence of serious side effects (compared to other medications, such as COX-2 inhibitors and other NSAIDs). Read more...
By: Thomas E. Hyde, DC

COX-2 inhibitors - Celebrex and Bextra information
October 7, 2003 (Updated March 23, 2005)
Due to the new label warnings for Bextra and recent concerns about COX-2 inhibitor health risks, it’s especially important for patients to follow Celebrex and Bextra usage recommendations and know when to consult a physician. This article clearly explains the known side effects of Celebrex and Bextra as well as the important new guidelines from the FDA. Read more...
By: Donald Frisco, MD

Celebrex - COX-2 inhibitor
October 7, 2003 (Updated March 23, 2005)
Celebrex (chemical name celecoxib) is a COX-2 inhibitor drug commonly prescribed for arthritis and other types of back pain. Celebrex works by reducing inflammation, which often is a component of back pain and neck pain. This article gives specific information about safe use of Celebrex, including dosage, potential side effects and precautions for taking the COX-2 inhibitor. Read more...
By: Donald Frisco, MD

NSAIDs: non-steroidal anti-inflammatory drugs
October 1999 (Updated March 2, 2005)
Because most episodes of back pain have an inflammatory component, anti-inflammatory medication is often an effective treatment option. NSAIDs (non-steroidal anti-inflammatory drugs) work like aspirin by limiting the formation of inflammation, but have fewer gastrointestinal side effects (such as gastritis or ulcers) than aspirin. One popular type of NSAID is COX-2 inhibitors, often used for arthritis and back pain. Read more...
By: Peter F. Ullrich, Jr., MD

Understanding COX-2 inhibitor side effects
February 9, 2005
Following the Vioxx recall, the FDA issued a new advisory for physicians prescribing Celebrex, Bextra and other NSAIDs to their patients. This article summarizes the recent study findings and FDA recommendations regarding COX-2 inhibitors and naproxen, and provides several guidelines for safe use of these medications for arthritis and back pain. Read more...
By: Peter F. Ullrich, Jr., MD

Safe use of COX-2 inhibitors and other NSAIDs
February 9, 2005
In light of new information about health risks associated with COX-2 inhibitors and some other NSAIDs, treatment options will vary from patient to patient based on individual risk factors, treatment needs and past experiences taking NSAIDs. Patients are recommended to meet with a physician to determine the safest and most effective arthritis and back pain medications. Read more...
By: Peter F. Ullrich, Jr., MD

Vioxx recall and recommendations
January 31, 2005
Since the voluntary recall of Vioxx, a brand of COX-2 inhibitor commonly prescribed for arthritis and different types of back pain, many patients have concerns about other brands of COX-2 inhibitors such as Bextra and Celebrex. This article explains the events that led to the Vioxx recall and outlines the current FDA recommendations for patients using COX-2 inhibitors and other NSAIDs. Read more...
By: Gunnar B.J. Andersson, MD, PhD

COX-2 inhibitors - Celebrex
December 1999
COX-2 inhibitors such as Celebrex represent a significant advancement in non-steroidal anti-inflammatory treatment for pain because, while they are as efficacious as older NSAIDs, they have far less risk of side effects (such as blood thinning or stomach ulceration). Read more...
By: Alan J. Bridges, MD

Arthritis and NSAIDs
December 1999
The most frequently prescribed medications for arthritis pain are NSAIDs and specifically COX-2 inhibitors. NSAIDs help with arthritis pain because they are both analgesic (painkillers) and have an anti-inflammatory effect. It is estimated that 2 to 4 million Americans use NSAIDs (such as COX-2 inhibitors) on a daily basis. Read more...
By: Alan J. Bridges, MD

Medications for back pain and neck pain
October 1999
There are multiple over-the-counter (non-prescription) and prescription medications that can be helpful in relieving back pain and addressing related symptoms while an episode of low back pain is getting better. This article covers a wide range of medications, such as NSAIDs, COX-2 inhibitors and pain relievers. Read more...
By: Peter F. Ullrich, Jr., MD

Additional patient resources

Are your medications making you sick? – Spine-health.com Newsletter
While the recent media attention to certain drugs (such as COX-2 inhibitors and other NSAIDs) has raised a red flag for many patients, the sometimes misleading or contradictory headlines have also created confusion and unnecessary fear for many. This newsletter explains some of the potential side effects and risks of several commonly used drugs for back pain, including COX-2 inhibitors, other NSAIDs, acetaminophen and anti-depressants. Read more...

Please note that these additional patient resources (such as The Back-to-Back Forum and Newsletters) on Spine-health.com are not peer-reviewed by the Spine-health.com Medical Advisory Board. They are provided as additional resources for patients to learn from each others’ experiences and to gain information from our popular newsletters.


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